Read all of this leaflet carefully before you start taking this medicine because it contains
important information for you.
• Keep this leaflet. You may need to read it again.
• If you have any further questions, ask your doctor or pharmacist.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them,
even if their signs of illness are the same as yours.
• If you get any side effects to talk to your doctor or pharmacist. This includes any possible side
effects not listed in this leaflet.
What is in this leaflet
- What Disulfiramtablets are and what they are used for
- What you need to know before you take Disulfiramtablets
- How to take Disulfiramtablets
- Possible side effects
- How to store Disulfiramtablets
- Contents of the pack and other information
- What Disulfiram tablets are and what they are used for
Disulfiram is used as a supportive agent in the treatment of alcoholism. When you drink alcohol it is
changed in the body into acetaldehyde, disulfiram blocks the enzyme which breaks down
acetaldehyde. This leads to an increased level of acetaldehyde in the blood causing unpleasant
physical reactions.
Disulfiram is used in the treatment of people with drinking problems. If you are treated with
Disulfiram tablets and drink alcohol you will experience unpleasant physical reactions, which may
stop you from drinking further alcohol.
- What you need to know before you take Disulfiram tablets
Do not take Disulfiram tablets if you have:
• an allergy (hypersensitivity) to disulfiram or any of the other ingredients of this medicine (listed in
section 6)
• severe heart disease or heart failure
• high blood pressure
• severe psychiatric or personality disorder
• had a stroke.
• recently consumed alcohol
Warnings and precautions
Talk to your doctor or pharmacist before taking Disulfiramtablets if you have:
• kidney, liver or lung disease
• diabetes
• low blood pressure
• brain damage
• epilepsy.
Children and adolescents
Do not give this medicine to children.
Other medicines and Disulfiram
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other
medicines, including medicines obtained without a prescription. Especially:
• warfarin (reduces blood clotting)
• phenytoin and paraldehyde (to treat epilepsy)
• theophylline (to treat asthma)
• chlordiazepoxide and diazepam (to treat anxiety)
• pethidine and morphine (painkillers)
• amphetamines (stimulants)
• pimozide, and chlorpromazine (to treat mental illnesses)
• isoniazid metronidazole, rifampicin (to treat infections)
• amitriptyline (to treat depression)
Other precautions
Certain foods, liquid medicines, remedies, tonics, toiletries, perfumes and sprays may contain enough
alcohol to cause a Disulfiram tablet -alcohol reaction. Caution should also be exercised with low
alcohol and “non-alcoholic” or “alcohol-free” beers and wines. If enough is taken they may produce
unpleasant reactions.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask
your doctor or pharmacist for advice before taking this medicine.
The use of Disulfiramtablet during the first 3 months of pregnancy or breast-feeding is not advised
and should only be used if directed by your doctor.
Driving and using machines
Disulfiram tablets may cause drowsiness or tiredness (see ‘4. Possible side effects’). If you are
affected do not drive or operate machinery.
Disulfiram and lactose
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor
before taking this medicinal product
Disulfiram and sodium.
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium-free’
Disulfiram and Alcohol
If you drink alcohol during or within 2 weeks of stopping Disulfiram tablets, or you have been
exposed to alcohol from other sources (see ‘Other precautions’) a Disulfiram-alcohol reaction may
occur. The reaction is unpredictable and symptoms may be severe or life-threatening. Symptoms
include; flushing of the face and neck, increased body temperature, sweating, feeling or being sick,
itchy skin or rash caused by an allergic reaction (pruritis, urticaria) anxiety, dizziness, headache,
blurred vision, difficulty breathing, palpitations, rapid breathing.
In severe cases; rapid heartbeat, low blood pressure, abnormally slow breathing, chest pain, abnormal
heart rhythm, coma or fits may occur.
Rare complications may include; high blood pressure, breathing problems, blood disorders.
If you get some of the symptoms, contact your doctor.
The Disulfiram-alcohol reaction can occur within 15 minutes after drinking alcohol and may last
several hours.
- How to take Disulfiram tablets
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist
if you are not sure. A check-up is advised before starting treatment to check you are suitable for
treatment.
Treatment with Disulfiramtablets is usually started in a hospital or specialised clinic. It is important
that you have not drunk alcohol for at least 24 hours before taking the first dose. Swallow the tablets
with water.
The recommended dose is:
• Adults and the elderly:
Initially 4 tablets (800mg) on day 1, then 3 tablets (600mg) on day 2, then 2 tablets (400mg) on day 3
and then 1 tablet (200mg) on days 4 and 5.
Then ½ to 1 tablet (100mg – 200mg) a day for as long as told by your doctor, but for no longer than
six months without review.
The tablet can be divided into equal halves.
If you take more than you should
If you (or someone else) swallow a lot of tablets at the same time, or you think a child may have
swallowed any, contact your nearest hospital casualty department or tell your doctor immediately.
Signs of an overdose include; feeling or being sick, stomach pain, diarrhoea, drowsiness, mental
disorders, tiredness, rapid heartbeat, rapid breathing, high body temperature, low blood pressure, loss
of muscle control, high blood sugar, changes in the blood (as seen in blood tests). Severe cases may
result in coma, fits or death.
If you forget to take the tablets
If you forget to take a dose, and you do not remember it within 12 hours, you should not take it. Do
not take a double dose to make up for a forgotten dose.
If you stop taking Disulfiram tablets
Speak to your doctor or pharmacist before stopping treatment with Disulfiram.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist. - Possible side effects
Like all medicines, Disulfiramtablets can cause side effects, although not everybody gets them.
Stop taking this medicine and immediately contact a doctor if you experience any of the following:
• allergic skin reactions such as itching and redness.
Tell your doctor if you notice any of the following side effects or notice any other effects not listed:
• depression, paranoia, schizophrenia, mania,
• decreased sexual desire
• drowsiness and fatigue (especially at the start of treatment)
• damage/inflammation of peripheral nerves (causing pain and loss of sensation in hands and feet)
• inflammation of the optic nerve
• encephalopathy (brain disease)
• feeling or being sick
• bad breath
• inflammation of the liver (hepatitis), damage to liver cells, liver failure
• rash
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects
not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at
www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App
Store.
By reporting side effects you can help provide more information on the safety of this medicine.
- How to store Disulfiram tablets
Keep this medicine out of the sight and reach of children.
This medicine does not require any special storage conditions.
Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The
the expiry date refers to the last day of that month.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to
throw away medicines you no longer use. These measures will help protect the environment. - Contents of the pack and other information
What Disulfiram tablets contain
• The active substance is disulfiram. Each tablet contains 200 mg of disulfiram.
• The other ingredients are microcrystalline cellulose, lactose, stearic acid, sodium starch glycolate,
colloidal anhydrous silica and magnesium stearate.
What Disulfiram tablets look like and contents of the pack
White to off-white, round, flat-faced, bevelled-edge uncoated tablets debossed with “I 99” on one side
and breakline on the other side with a diameter of 11 mm.
The tablets are packed in plastic containers. Pack size is 50 tablets.
Manufactured in India by:
TAJ LIFE SCIENCES PVT. LTD.
Unit No. 214, Old Bake House,
Bake House Lane, Fort,
Mumbai-400001
at: Ahmedabad- Gujarat, INDIA.
Ho.NO.+91 8448 444 095
Toll Free Phone: (1800-222-434 / 1800-222-825)